By Kian Fan Chung
During this ebook, top researchers in drugs and molecular pharmacology clarify the mobile mechanisms that keep watch over airway delicate muscle. The capacity during which those are disrupted in illness, and the pharmacologic thoughts in which they're changed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity presents the clinician with the hottest details on one of many middle physiological strategies in airway ailment, and provides insights into present and destiny methods to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most recent learn to bronchodilator therapyMulti-contributed textual content, co-coordinated via of the top specialists within the box.
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Extra resources for Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology
Consequences of long-term inflammation. Airway remodeling. Clin Chest Med 21, 331–343. , Fabry, B. et al. (2003). Intracellular stress tomography reveals stress focusing and structural anisotropy in the cytoskeleton of living cells. Am J Physiol 285, C1082–C1090. Hubmayr, R. , Shore, S. , Fredberg, J. J. et al. (1996). Pharmacological activation changes stiffness of cultured human airway smooth muscle cells. Am J Physiol 271, C1660–C1668. Huxley, A. F. (1957). Muscle structure and theories of contraction.
J Physiol 519, 829–840. , Tang, D. , Wu, M. F. et al. (2000). Role of Rho in Ca2+ -insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle. Am J Physiol 279, C308– C318. Meiss, R. A. (1999). Influence of intercellular tissue connections on airway muscle mechanics. J Appl Physiol 86, 3–4. Mijailovich, S. M. (2003). Dynamics of airway closure: critical smooth muscle activation in normals and asthmatics. Am J Respir Crit Care Med 167, A183. Mijailovich, S. , Butler, J. P. and Fredberg, J.
Hedges, J. , Oxhorn, B. , Carty, M. et al. (2000). Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol 278, C718–C726. Hirshman, C. A. and Emala, C. W. (1999). Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho. Am J Physiol 277, L653–L661. Hirst, S. , Twort, C. H. C. and Lee, T. H. (2000). Differential effects of extracellular matrix proteins on human airway smooth muscle cell proliferation and phenotype. Am J Respir Cell Mol Biol 23, 335–344.
Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology by Kian Fan Chung