By Horace W. Davenport
This ebook examines the historical past of experimental learn in gastric secretion and digestion. the writer identifies the medical questions that experience occupied researchers and discusses the experiments that experience resulted in their options. via keeping apart facets of experimental learn and tracing their evolution through the years, the booklet presents gastric physiologists and gastroenterologists with a fantastic knowing of the highbrow background in their box.
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Extra resources for A History of Gastric Secretion and Digestion: Experimental Studies to 1975
Thesis at the Califomia Institute ofTechnology on the presence of carbonic anhydrase in the parietal cells, I was quite naturally thinking about the mechanism of acid seeretion. I encountered two abstracts by Martin E. Hanke, a physiological ehernist at the University ofChieago. " Hanke demonstrated the presence of a "chloroesterase" in extracts offresh gastric tissue. The extract appeared to catalyze the hydrolysis of glycerol dichlorhydrin, glycerol monochlorhydrin, monochloracetic acid, and dichloracetic acid.
Furthermore, Fisher said that ifbromide and chloride merely follow hydrogen ions on account ofthe potential established by the positive charges on the hydrogen ion, 26 / A HISTORY OF GASTRIC SECRETION AND DIGESTION their rates of entry into gastric juice should be proportional to their concentrations in plasma multiplied by their mobilities in water. Thus: [Br-]Ki [cngj [Br-]p Usr (1-1) = [cnp ua ' where U8 • and U0 are the mobilities in water, p is plasma, and gj is gastric juice. A secretion constant could be calculated: [Br-]gj [Cnp Ua ]Ki [Br ]p UBr .
In early studies reported in 1947, values of20 to 40 were obtained, 89 andin 1950 N. B. Myant and bis colleagues at University College Hospital in London obtained values averaging 40 in three patients. 90 In 1950 E. E. Mason and H. S. w ... 2 3 4 5 • 7 \< • ........ ·--·-· ~--~·---:---~-- "",. _r:.. · . ,. ·.. :.. e• 3 4 _: 2 3 4 5 6 7 ·?! 11 J .. 4 5 _,F'"· . I II 7 c Figure 1-15. A: Ordinates, ratio of the concentration of iodide in gastric juicetothat in plasma. Abscissae, plasma iodide concentration in millimoles per Iiter.
A History of Gastric Secretion and Digestion: Experimental Studies to 1975 by Horace W. Davenport