Download PDF by Qingbo Xu: A Handbook of Mouse Models of Cardiovascular Disease

By Qingbo Xu

ISBN-10: 0470016108

ISBN-13: 9780470016107

ISBN-10: 0470028785

ISBN-13: 9780470028780

The provision of well-defined genetic lines and the facility to create transgenic and knockout mice makes mouse types tremendous important biomedical instruments. Their suitability as an experimental procedure for cardiovascular study depends upon the person investigator’s skill to govern the mice surgically. Many mouse types require microsurgical suggestions, which hitherto couldn't be played with out useful education. This entire guide permits scientists to boost those versions of their personal laboratories.A instruction manual of Mouse types of Cardiovascular Disease is the 1st publication to deal with pathology in mouse versions of center disorder, delivering the reader with crucial details on technical assays in artificially created types. It contains historical past details on person cardiovascular illnesses, describes certain tools and fabrics used for setting up every one mouse version, discusses the issues that could seem within the experiments, and gives examples of functions of the model.A instruction manual of Mouse types of Cardiovascular Disease:Describes mouse versions of all very important cardiovascular ailments, together with atherosclerosis, atrial traumatic inflammation and thrombosisFeatures movies of key experimental tactics at the accompanying CD, permitting researchers to profit the concepts by way of at once observing the entire operational procedureDescribes tips on how to identify each one experimental version with specific protocols and pointers on facing universal operational problemsHighlights capability purposes of every version in components similar to pathogenesis, gene move, therapy and pathophysiologyThis instruction manual is a useful source for researchers in heart problems, pathology, body structure, attracted to the mechanism of vascular issues and healing ways. it's also proper to clinicians looking to comprehend the pathology of heart problems and the explanation for interventions, and of curiosity to the pharmaceutical and all these fascinated about drug discovery/development for heart problems.

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Additional resources for A Handbook of Mouse Models of Cardiovascular Disease

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Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res 2001; 89: 125–130. 49. Mehrabian M, Allayee H, Wong J, et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 2002; 91: 120–126. 50. Kuhn H, Anton M, Gerth C, Habenicht A. Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog.

Science 1995; 270: 467–470. 31. Bunney WE, Bunney BG, Vawter MP, et al. Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Am J Psychiatry 2003; 160: 657–666. 32. Doerge RW. Mapping and analysis of quantitative trait loci in experimental populations. Nat Rev Genet 2002; 3: 43–52. 33. Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature 2000; 405: 827–836. 34. Lawn RM, Wade DP, Garvin MR, et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway.

53. Wang X, Korstanje R, Higgins D, Paigen B. Haplotype analysis in multiple crosses to identify a QTL gene. Genome Res 2004; 14: 1767–1772. 3 Transgenic and gene-targeted mice in the study of hyperlipidemia Yadong Huang Gladstone Institute of Cardiovascular Disease and Departments of Pathology and Neurology, University of California, San Francisco, CA, USA Introduction Hyperlipidemia, characterized by elevated plasma levels of cholesterol or triglyceride or both, is among the public health problems worldwide.

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A Handbook of Mouse Models of Cardiovascular Disease by Qingbo Xu


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